Methylparaben → HCID 57743211, compound

HRID 1095105Notes

Reaction equation

HRID 1095105 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[OH:11][C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[CH3:19][O:18][C:16](=[O:17])[C:15]1[CH:20]=[CH:21][C:12]([O:11][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:9][C:6]=2[CH:7]=[O:8])=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 7456MethylparabenHCID 11430Potassium CarbonateHCID 27735865-Chloro-2-fluorobenzaldehyde

Product 1

HCID 57743211HCID 57743211, compoundYield 80.7%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-chloro-2-fluorobenzaldehyde (4.2 g, 26 mmol) (Alfa) was reacted with methyl 4-hydroxybenzoate (4 g, 28 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 4-(4-chloro-2-formyl-phenoxy)-benzoic acid methyl ester as a white solid (Yield 6.1 g, 80%).

Sources & evidence

ORD record
ord-288b6cc7099a412a8ab078979e2d1af2
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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