Potassium Carbonate → HCID 57743425, compound

HRID 1095117Notes

Reaction equation

HRID 1095117 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([I:10])=[CH:6][C:3]=1[CH:4]=[O:5].[C:11]([C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)#[N:12].C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[CH:4]([C:3]1[CH:6]=[C:7]([I:10])[CH:8]=[CH:9][C:2]=1[O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]#[N:12])=[CH:14][CH:15]=1)=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 130194-CyanophenolHCID 162170582-Fluoro-5-iodobenzaldehyde

Product 1

HCID 57743425HCID 57743425, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 2-fluoro-5-iodobenzaldehyde (2 g, 8 mmol) (Aldrich) was reacted with 4-cyanophenol (1.43 g, 12 mmol) and K2CO3 in N,N-dimethylacetamide to give 4-(2-formyl-4-iodo-phenoxy)-benzonitrile as a light yellow solid (Yield 1.9 g, 70.4%).

Sources & evidence

ORD record
ord-f53381edb0464f7cbe7425929c0c1d3c
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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