4-Methoxyphenol → HCID 57743255, compound

HRID 1095119Notes

Reaction equation

HRID 1095119 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([I:10])=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[I:10][C:7]1[CH:8]=[CH:9][C:2]([O:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)=[C:3]([CH:6]=1)[CH:4]=[O:5]

Participants

5

Reactant 3

HCID 90154-MethoxyphenolHCID 11430Potassium CarbonateHCID 162170582-Fluoro-5-iodobenzaldehyde

Product 1

HCID 57743255HCID 57743255, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 2-fluoro-5-iodobenzaldehyde (1.2 g, 4.8 mmol) (Aldrich) was reacted with 4-methoxyphenol (0.71 g, 5.76 mmol) and K2CO3 in N,N-dimethylacetamide to give 5-iodo-2-(4-methoxy-phenoxy)-benzaldehyde as a yellow oil (Yield 1.12 g, 66%).

Sources & evidence

ORD record
ord-c58583b6d6b64f41ac77f7c2e9617af4
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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