Potassium Carbonate → HCID 57743200, compound

HRID 1095131Notes

Reaction equation

HRID 1095131 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][OH:21])=[CH:14][CH:13]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][CH2:20][OH:21])=[CH:16][CH:17]=2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 824523-(4-Hydroxyphenyl)propanolHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 57743200HCID 57743200, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (5.5 g, 27 mmol) (Alfa) was reacted with 3-(4-hydroxyphenyl)-1-propanol (4.5 g, 30 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 5-bromo-2-[4-(3-hydroxy-propyl)-phenoxy]-benzaldehyde as a brown oil (Yield 9 g, 99%).

Sources & evidence

ORD record
ord-ec54b7395a55432085a641e23ee3a2be
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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