Potassium Carbonate → HCID 57743367, compound

HRID 1095137Notes

Reaction equation

HRID 1095137 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([I:10])=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][N:12]1[C:16]([CH3:17])=[C:15]([OH:18])[C:14]([CH3:19])=[N:13]1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[I:10][C:7]1[CH:8]=[CH:9][C:2]([O:18][C:15]2[C:14]([CH3:19])=[N:13][N:12]([CH3:11])[C:16]=2[CH3:17])=[C:3]([CH:6]=1)[CH:4]=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 12498505trimethyl-1H-pyrazol-4-olHCID 162170582-Fluoro-5-iodobenzaldehyde

Product 1

HCID 57743367HCID 57743367, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 2-fluoro-5-iodobenzaldehyde (5.84 g, 23.4 mmol) (Aldrich) was reacted with 1,3,5-trimethyl-1H-pyrazol-4-ol (3.24 g, 25.7 mmol) and K2CO3 in N,N-dimethylacetamide to give 5-iodo-2-(1,3,5-trimethyl-1H-pyrazol-4-yloxy)-benzaldehyde as a yellow solid (Yield 8.1 g, 97%).

Sources & evidence

ORD record
ord-88d8958e6b2b4b7bb37f4e21792483f7
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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