Potassium Carbonate → HCID 57743358, compound

HRID 1095139Notes

Reaction equation

HRID 1095139 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH3:11][N:12]1[C:16]([CH3:17])=[C:15]([OH:18])[C:14]([CH3:19])=[N:13]1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:18][C:15]2[C:14]([CH3:19])=[N:13][N:12]([CH3:11])[C:16]=2[CH3:17])=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 7363275-Bromo-2-fluorobenzaldehydeHCID 12498505trimethyl-1H-pyrazol-4-ol

Product 1

HCID 57743358HCID 57743358, compoundYield 100.3%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluoro-benzaldehyde (2 g, 10 mmol) (Acros) was reacted with 1,3,5-trimethyl-1H-pyrazol-4-ol (1.3 g, 10 mmol) and K2CO3 in N,N-dimethylacetamide to give 5-bromo-2-(1,3,5-trimethyl-1H-pyrazol-4-yloxy)-benzaldehyde as a white solid (Yield 3.1 g, 100%).

Sources & evidence

ORD record
ord-cb48b1e68cf642b8ac3ef765a37d7555
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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