2,6-Dichlorobenzaldehyde → HCID 28604100, compound

HRID 1095145Notes

Reaction equation

HRID 1095145 reaction equation
Cl[C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([Cl:10])[C:3]=1[CH:4]=[O:5].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Cl:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]([O:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[C:3]=1[CH:4]=[O:5]

Participants

5

Reactant 3

HCID 67372,6-DichlorobenzaldehydeHCID 90154-MethoxyphenolHCID 11430Potassium Carbonate

Product 1

HCID 28604100HCID 28604100, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 2,6-dichlorobenzaldehyde (2.7 g, 15 mmol) (Aldrich) was reacted with 4-methoxyphenol (1.8 g, 15 mmol) and K2CO3 in N,N-dimethylacetamide to give 2-chloro-6-(4-methoxy-phenoxy)-benzaldehyde as a yellow oil (Yield 3.2 g, 80%).

Sources & evidence

ORD record
ord-c9c5beb95a1346c3b6376d28f808160b
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

Loading…