3-Fluorobenzaldehyde → HCID 5027553, compound

HRID 1095181Notes

Reaction equation

HRID 1095181 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O>CO.N1CCCCC1>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[CH:16][C:15]3[CH:18]=[CH:19][CH:20]=[C:13]([F:12])[CH:14]=3)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 680093-FluorobenzaldehydeHCID 7363446-Chloro-1,3-dihydroindol-2-one

Product 1

HCID 5027553HCID 5027553, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8082PiperidineSolvent

Conditions

Temperature
75 °C

Procedure

6-Chloro-1,3-dihydro-indol-2-one (Aldrich, 7.5 g, 44.92 mmol) was treated with 3-fluoro-benzaldehyde (Aldrich, 5.57 g, 44.92 mmol) in methanol (50 mL) and piperdine (0.2 mL). The mixture was heated at 75° C. overnight and then cooled to room temperature. The solid was filtered and dried to give a yellow solid. 8.8 g.

Workup

  1. temperaturecooled to room temperature
  2. filtrationThe solid was filtered
  3. customdried
  4. customto give a yellow solid

Sources & evidence

ORD record
ord-0c2c99ac9d5c47e7ac99552acc496e02
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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