反应详情

A mixture of Formononetin (1, 1.34 g, 5 mmol) (G. Y. Gao, et. al. Bioorg. Med. Chem. 2003, 11, 4069), K2CO3 (0.69 g, 5 mol), 2-bromopropane (1.23 g, 10 mmol) and DMF (10 mL) was refluxed with stirring for 3 hrs (TLC monitoring). The mixture was then cooled and evaporated in vacuo to give a residue which was treated with H2O (50 mL). The precipitate thus obtained was collected, purified by column chromatography (MeOH/CH2Cl2=1:100), and crystallization from EtOH to give 2 (1.46 g, 94% yield). M.p.: 245-246° C.

1. temperaturewas refluxed
2. temperatureThe mixture was then cooled
3. customevaporated in vacuo
4. customto give a residue which
5. customThe precipitate thus obtained
6. customwas collected
7. custompurified by column chromatography (MeOH/CH2Cl2=1:100), and crystallization from EtOH