反应详情

温度

65 °C

To a flask was added quinoline-2,8-diol (20.0 g, 124.1 mmol), K2CO3 (17.15 g, 124.1 mmol), benzyl bromide (14.76 ml, 124.1 mmol) and DMF (124.1 ml, 124.1 mmol). The resulting mixture was heated to 65° C. overnight. The reaction mixture was poured into 1000 ml water and stirred for 5 hours, filtered solids and then washed with 1000 ml diethyl ether to yield 26.5 g (85% yield) of desired product.

1. filtrationfiltered solids
2. washwashed with 1000 ml diethyl ether