反应详情

温度

100 °C

Sodium azide (1.7 g) and triethylamine hydrochloride (3.5 g) were added to a DMF (80 mL) solution of methyl 2-cyano-6-phenylpyridine-4-carboxylate (2 g), and stirred overnight at 100° C. With cooling with ice, diluted hydrochloric acid was added to it, and extracted with a mixed solution of chloroform/methanol=10/1. The organic layer was washed with water and saturated saline water, dried with anhydrous sodium sulfate, filtered, and the solvent was evaporated away to obtain the title compound as a brown solid.

1. additionwas added to it
2. extractionextracted with a mixed solution of chloroform/methanol=10/1
3. washThe organic layer was washed with water and saturated saline water
4. dry with materialdried with anhydrous sodium sulfate
5. filtrationfiltered
6. customthe solvent was evaporated away