Hydrochloric Acid → HCID 178498539, compound

HRID 1096964Notes

Reaction equation

HRID 1096964 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].Cl.C(N(CC)CC)C.[C:13]([C:15]1[CH:16]=[C:17]([CH:22]=[C:23]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=1)[C:18]([O:20][CH3:21])=[O:19])#[N:14].Cl>CN(C=O)C>[CH2:26]([O:25][C:23]1[CH:22]=[C:17]([CH:16]=[C:15]([C:13]2[NH:14][N:3]=[N:2][N:1]=2)[CH:24]=1)[C:18]([O:20][CH3:21])=[O:19])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 57930932HCID 57930932, compound

Product 1

HCID 178498539HCID 178498539, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

Sodium azide (1.5 g) and triethylamine hydrochloride (3.2 g) were added to a DMF (70 mL) solution of methyl 3-cyano-5-benzyloxybenzoate (2.07 g), and stirred at 100° C. for 6 hours and then overnight at room temperature. With cooling with ice, diluted hydrochloric acid was added to it, the precipitate was taken out through filtration, washed with water, and dried to obtain the title compound as a white powder.

Workup

  1. customovernight
  2. customat room temperature
  3. additionwas added to it
  4. filtrationthe precipitate was taken out through filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-6d66a2ad727048a38dc8e03e43808a5e
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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