反应详情

Methyl 4-bromo-3,5-dihydroxybenzoate (10 g) was dissolved in DMF (80 mL), and potassium carbonate (13.2 g) and ethyl iodide (7.6 mL) were added to it, and stirred overnight at room temperature. The reaction liquid was poured into water with cooling with ice, extracted with ethyl acetate, the organic layer was washed with water and saturated saline water, and dried with sodium sulfate. Sodium sulfate was removed through filtration, the filtrate was concentrated under reduced pressure, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/0 to 90/10) to obtain the title compound as a white solid.

1. customThe reaction liquid
2. temperaturewith cooling with ice
3. extractionextracted with ethyl acetate
4. washthe organic layer was washed with water and saturated saline water
5. dry with materialdried with sodium sulfate
6. customSodium sulfate was removed through filtration
7. concentrationthe filtrate was concentrated under reduced pressure
8. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate=1/0 to 90/10)