Dimethylformamide → HCID 57930995, compound

HRID 1096984Notes

Reaction equation

HRID 1096984 reaction equation
[CH2:1](I)[CH3:2].CN(C=O)C.[Br:9][C:10]1[C:19]([O:20][CH3:21])=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][C:11]=1[OH:22].C(=O)([O-])[O-].[K+].[K+]>O>[Br:9][C:10]1[C:19]([O:20][CH3:21])=[CH:18][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][C:11]=1[O:22][CH2:1][CH3:2]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 57930973HCID 57930973, compound

Product 1

HCID 57930995HCID 57930995, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 1.0-liter egg plant-type flaks, ethyl iodide (6.91 mL, 86 mmol) was added to a DMF (150 mL) solution of the previously-obtained methyl 4-bromo-3-hydroxy-5-methoxybenzoate and potassium carbonate (11.9 g, 86 mmol), and stirred overnight at room temperature. Water was added to the reaction solution, the formed precipitate was taken out through filtration and dried under reduced pressure to obtain the title compound as a colorless solid.

Workup

  1. filtrationthe formed precipitate was taken out through filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-764ac02837e64c8ab08283cb874b6954
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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