反应详情

温度

60 °C

4-Imidazo[1,2-b]pyridazin-7-yl-pyridin-2-ol (1 eq, 0.17 mmol, 36 mg), 1-(3-chloropropyl)piperidine monohydrochloride (1.5 eq, 0.255 mmol, 52 mg) and sodium iodide (1.5 eq, 0.254 mmol, 37.9 mg) are dissolved in DMF (1 ml) and heated at 60° C. for 16 h to give a black solution. The reaction mixture is then poured into aq. sat. NaHCO3 and the organic phase is extracted with CH2Cl2. The organic phase is washed with brine, dried over MgSO4, filtered and evaporated to dryness to afford 4-imidazo[1,2-b]pyridazin-7-yl-1-(3-piperidin-1-yl-propyl)-1H-pyridin-2-one; [M+H]+=338

1. customto give a black solution
2. extractionthe organic phase is extracted with CH2Cl2
3. washThe organic phase is washed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated to dryness