Methylamine → HCID 86227598, compound

HRID 1097572Notes

Reaction equation

HRID 1097572 reaction equation
[Cl:1][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:16]([N:18](CC)CC)C.CN>O1CCCC1>[CH3:16][NH:18][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([Cl:1])[C:11]=1[N+:12]([O-:14])=[O:13]

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8471TriethylamineHCID 27851382,4-Dichloro-3-nitroquinoline

Product 1

HCID 86227598HCID 86227598, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The method described in Part A of Example 4 was used to treat 2,4-dichloro-3-nitroquinoline (10.0 g, 40.8 mmol) with triethylamine (8.53 mL, 61.2 mmol) and methylamine (20.41 mL of a 2 M solution in tetrahydrofuran, 40.82 mmol) to provide 9.45 g of N-methyl-2-chloro-3-nitroquinolin-4-amine as a yellow powder.

Sources & evidence

ORD record
ord-ea1824ab72944f5395060772cf5ca62f
Source dataset
uspto-grants-2012_03
Patent number
US08143270B2

Reaction notes

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