反应详情

To a mixture of 2-pyridinecarbonitrile (3 g, 29 mmol) and potassium carbonate (4.1 g, 30 mmol) in EtOH (30 ml) was added water (15 ml) and, cautiously, hydroxylamine hydrochloride (2.9 g, 42 mmol) and then heated at reflux for 6 h, cooled and evaporated to dryness. The residue was treated with water (100 ml) and the suspended solid product filtered off, washed with water and dried to yield the title compound as a white solid (2.28 g, 57%).

1. temperatureat reflux for 6 h
2. temperaturecooled
3. customevaporated to dryness
4. additionThe residue was treated with water (100 ml)
5. filtrationthe suspended solid product filtered off
6. washwashed with water
7. customdried