反应详情

A solution of 4-bromo-2-trifluoromethyl-benzenesulfonyl chloride (5.00 g, 15.46 mmol) in THF (5 ml) was added to a solution of morpholine (1.62 ml, 18.55 mmol) and triethylamine (2.15 ml, 15.46 mmol) in tetrahydrofurane. The reaction mixture was stirred for 12 h at RT. Ethyl acetate (80 ml) was added, the organic phase was separated and washed with water (20 ml), hydrochloric acid (1 M, 20 ml) and brine (20 ml) and dried over sodium sulphate. After evaporation the product was obtained (5.708 g, 99%) and used in the next step without further purification.

1. customthe organic phase was separated
2. washwashed with water (20 ml), hydrochloric acid (1 M, 20 ml) and brine (20 ml)
3. dry with materialdried over sodium sulphate
4. customAfter evaporation the product
5. customwas obtained (5.708 g, 99%)
6. customused in the next step without further purification