6-Iodoquinoline → HCID 178422846, compound

HRID 1101944Notes

Reaction equation

HRID 1101944 reaction equation
Cc1ccc2c(cnn2C2CCCCO2)c1B1OC(C)(C)C(C)(C)O1.Ic1ccc2ncccc2c1>CC(=O)[O-].CC(=O)[O-].CC(C)(C)P(C1[CH][CH][CH][CH]1)C(C)(C)C.CC(C)(C)P(C1[CH][CH][CH][CH]1)C(C)(C)C.CCc1cc(CC)cc(CC)c1.CCc1cccc(CC)c1.CN(C)C=O.CO.Cc1ccccc1.O.[Fe].[Na+].[OH-].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1

Participants

13

Reactant 2

HCID 203985536-IodoquinolineHCID 134714813HCID 134714813, compound

Product 1

HCID 178422846HCID 178422846, compoundYield 74.94%

Reagents, catalysts & solvents 10

HCID 14798Sodium HydroxideReagentHCID 167845palladium(II) acetateCatalystHCID 178454871C26H44FeP2CatalystHCID 887MethanolSolventHCID 962WaterSolvent2×HCID 1140TolueneSolventHCID 6228DimethylformamideSolventHCID 76021,3,5-TriethylbenzeneSolventHCID 88641,3-DiethylbenzeneSolventHCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-fdbd2b179c324922b8ec507a82629bb9
Source dataset
Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions
Original link
View source

Reaction notes

Loading…