反应详情

To a solution of 132.6 g of o-nitrobenzenesulfonyl chloride in 700 ml of tetrahydrofuran was added 88.5 g of diethylamine at 5°-15°. The reaction mixture was stirred at room temperature for 1 hour before the precipitated diethylamine hydrochloride was removed by filtration. The filtrate was evaporated to dryness in-vacuo and the residue dissolved in 1-chlorobutane. The 1-chlorobutane solution was washed with water, dried over magnesium sulfate and evaporated in-vacuo to give 122.4 g of o-nitro-N,N-diethylbenzenesulfonamide as a dark oil.

1. customwas removed by filtration
2. customThe filtrate was evaporated to dryness in-vacuo
3. dissolutionthe residue dissolved in 1-chlorobutane
4. washThe 1-chlorobutane solution was washed with water
5. dry with materialdried over magnesium sulfate
6. customevaporated in-vacuo