1,1'-Carbonyldiimidazole → HCID 178475114, compound

HRID 1106110Notes

Reaction equation

HRID 1106110 reaction equation
[C:1]([N:4]([C:21](=[O:26])[C:22]([NH2:25])([CH3:24])[CH3:23])[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:16]=[C:15]([OH:17])[C:14]([C:18]([OH:20])=[O:19])=[CH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O>O1CCCC1>[N-:16]1[CH:15]=[CH:14][N:12]=[CH:11]1.[C:1]([N:4]([C:21](=[O:26])[C:22]([NH2:25])([CH3:23])[CH3:24])[C:5]1[CH:6]=[CH:7][C:8]([C:11]2[N:16]=[C:15]([OH:17])[C:14]([C:18]([OH:20])=[O:19])=[CH:13][N:12]=2)=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 178475113HCID 178475113, compound

Product 1

HCID 178475114HCID 178475114, compoundYield 142.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 5.6 g (15.7 mmol) of the above pyrimidine acid and 5.0 g (31 mmol) of carbonyldiimidazole in 100 ml tetrahydrofuran is stirred at 50° C. for 1/2 hr and at room temperature for 2 hrs. The mixture is filtered and the solids washed with ether and dried in vacuo affording 4.75 g of the title imidazolide.

Workup

  1. filtrationThe mixture is filtered
  2. washthe solids washed with ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-ed4309e5d0094ebfb80592f045a400ae
Source dataset
uspto-grants-1982_01
Patent number
US04311699

Reaction notes

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