Sodium hydride → HCID 53665391, compound

HRID 1106684Notes

Reaction equation

HRID 1106684 reaction equation
[H-].[Na+].[OH:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:13].Br[CH2:34][CH2:35][CH2:36][CH2:37][Cl:38]>O1CCCC1>[Cl:38][CH2:37][CH2:36][CH2:35][CH2:34][O:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[C:12]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])=[O:13]

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 813641-Bromo-4-chlorobutaneHCID 18789396HCID 18789396, compound

Product 1

HCID 53665391HCID 53665391, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydride is added to tetrahydrofuran solution of octadecyl 2-(2-hydroxyethyl)piperidinecarboxylate and the mixture is reacted at 0° C. Then, 1-bromo-4-chlorobutane is added to the reaction mixture and reacted to obtain octadecyl 2-(4-chlorobutoxyethyl)piperidinecarboxylate.

Workup

  1. customthe mixture is reacted at 0° C
  2. customreacted

Sources & evidence

ORD record
ord-28601a97ae6a4c399d4c5e6a2653298c
Source dataset
uspto-grants-2000_05
Patent number
US06057337

Reaction notes

Loading…