Hydrochloric Acid → HCID 18789974, compound

HRID 1106866Notes

Reaction equation

HRID 1106866 reaction equation
[Cl:1][C:2]1[CH:24]=[C:23]([NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH:22]=[CH:21][C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)[CH3:8].Cl.OS(O)(=O)=O.[NH4+].[Cl-]>C(OCC)(=O)C>[ClH:1].[Cl:1][C:2]1[CH:24]=[C:23]([NH:25][S:26]([CH3:29])(=[O:27])=[O:28])[CH:22]=[CH:21][C:3]=1[O:4][CH2:5][CH2:6][N:7]([CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)[CH3:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 18789852N-[3-Chloro-4-[2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]ethoxy]phenyl]methanesulfonamideHCID 18789914HCID 18789914, compound

Product 1

HCID 18789974HCID 18789974, compoundYield 197%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A portion (1.6 g, 3.6 mmol) of the 1-(2-chloro-4-methanesulfonamidophenoxy]-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane produced in (4) above was dissolved in ethyl acetate (50 ml) and, thereafter, HCl was injected in a gaseous state (H2SO4 +NH4Cl) into the resulting solution as it was stirred at ordinary temperatures, thereby forming a precipitate. When no more precipitate was formed, the solvent was evaporated to yield the titled compound 1-(2-chloro-4-methanesulfonamidophenoxy)-2-[N-(3,4-dimethoxyphenethyl)-N-methylamino]ethane hydrochloride (1.7 g) as a pale yellow solid mass.

Workup

  1. customforming a precipitate
  2. customWhen no more precipitate was formed
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-5f82b2d65e1b49749491e8d872873a62
Source dataset
uspto-grants-2000_05
Patent number
US06057358

Reaction notes

Loading…