2-Bromoethanol → HCID 21968525, compound

HRID 1107390Notes

Reaction equation

HRID 1107390 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:17][C@@:16]2([O:18][CH3:19])[C@@H:6]([CH2:7][C:8]3[C:20]4[C:11](=[CH:12][CH:13]=[CH:14][C:15]2=4)[NH:10][CH:9]=3)[NH:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:28][CH2:29][OH:30]>CN(C)C=O>[OH:30][CH2:29][CH2:28][N:5]1[C@H:6]2[C@@:16]([O:18][CH3:19])([C:15]3[CH:14]=[CH:13][CH:12]=[C:11]4[C:20]=3[C:8]([CH2:7]2)=[CH:9][NH:10]4)[CH2:17][C@@H:3]([CH2:2][OH:1])[CH2:4]1

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 70256914HCID 70256914, compound

Product 1

HCID 21968525HCID 21968525, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of 3 g of 8β-hydroxymethyl-10α-methoxy-ergoline, 3 g of potassium carbonate in 25 ml of dimethylformamide was added 1.3 g of 2-bromoethanol.

Sources & evidence

ORD record
ord-3b6b733681f94543a7d1f490acc5828f
Source dataset
uspto-grants-2000_05
Patent number
US06060483

Reaction notes

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