4-Chlorobenzoic Acid → 1-Phenyl-2-(phenylsulphonyl)ethan-1-one

HRID 1107450Notes

Reaction equation

HRID 1107450 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][CH:3]=1.CO[C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)C(O)=O.C1OC2C=CC(C(O)=O)=CC=2O1.COC1C=C(C=C(OC)C=1OC)C(O)=O.FC(F)(F)C1C=C(C=CC=1)C(O)=O.CN(C)C1C=C(C=CC=1)C(O)=O.C[S:75]([C:77]1C=CC(C(O)=O)=CC=1)=[O:76].CS(C1C=CC(C(O)=O)=CC=1)(=O)=[O:88].FC1C=C(C=C(F)C=1)C(O)=O.C1C2C(=CC=CC=2)C=CC=1C(O)=O.CN(C)C1C2C(=CC=CC=2)C=C(C(O)=O)C=1.COC1C=C2C(=CC=1)C=C(C(O)=O)C=C2.C1(C(C)C(O)=O)C=CC=CC=1.C1OC2C=CC(C(C)C(O)=O)=CC=2O1.C(Cl)(=O)C1C=CC=CC=1>>[C:6]([CH2:77][S:75]([C:13]1[CH:14]=[CH:15][CH:19]=[CH:20][CH:21]=1)(=[O:88])=[O:76])(=[O:8])[C:5]1[CH:4]=[CH:3][CH:2]=[CH:10][CH:9]=1

Participants

16

Reactant 15

HCID 63184-Chlorobenzoic AcidHCID 71232-Naphthoic acidHCID 71961,3-Benzodioxole-5-carboxylic acidHCID 7412Benzoyl chlorideHCID 83573,4,5-Trimethoxybenzoic AcidHCID 99633-(Trifluoromethyl)benzoic acidHCID 102962-Phenylpropionic acidHCID 114613-Methoxybenzoic AcidHCID 668373-(Dimethylamino)benzoic acidHCID 77670p-(Methylsulphonyl)benzoic acidHCID 1012653,5-Difluorobenzoic acidHCID 3491816-Methoxy-2-Naphthoic AcidHCID 49618924-Methanesulfinylbenzoic acidHCID 183996542-(1,3-Dioxaindan-5-yl)propanoic acidHCID 21188426HCID 21188426, compound

Product 1

HCID 769491-Phenyl-2-(phenylsulphonyl)ethan-1-one

Procedure

When the acid chloride of 4-chlorobenzoic acid, 3-methoxybenzoic acid, 3,4-methylenedioxybenzoic acid, 3,4,5-trimethoxybenzoic acid, 3-trifluoromethylbenzoic acid, 3-dimethylaminobenzoic acid, 4-methylthiobenzoic, 4-methylsulfinylbenzoic acid, 4methylsulfonylbenzoic acid, 3,5-difluorobenzoic acid, 2-naphthoic acid, 4-dimethylamino-2-naphthoic acid, 6-methoxy-2-naphthoic acid, 2-phenylpropionic acid and 2-(3,4-methylenedioxyphenyl) propionic acid are used in place of benzoyl chloride above, the corresponding substituted ketosulfones are prepared.

Workup

  1. customare prepared

Sources & evidence

ORD record
ord-1680a0eb66e74967bfeb508ad0125602
Source dataset
uspto-grants-2000_05
Patent number
US06060473

Reaction notes

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