Hydrochloric Acid → 2,3-Dimethyl-7-(1-diethylamino-2-hydroxyethyl)benzofuran hydrochloride

HRID 1107513Notes

Reaction equation

HRID 1107513 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH2:13][OH:14])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7].[ClH:20]>C(O)(C)C>[ClH:20].[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:15]([CH2:18][CH3:19])[CH2:16][CH3:17])[CH2:13][OH:14])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 154079562,3-Dimethyl-7-(1-diethylamino-2-hydroxyethyl)benzofuran

Product 1

HCID 187875182,3-Dimethyl-7-(1-diethylamino-2-hydroxyethyl)benzofuran hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.55 mg of 2,3-dimethyl-7-(1-diethylamino-2-hydroxyethyl)benzofuran and 100 ml of a 0.1N solution of hydrochloric acid in isopropanol are placed in a 100 ml round-bottom flask. The salt is concentrated under vacuum and recrystallized from ethyl acetate. 0.561 g of 2,3-dimethyl-7-(1-diethylamino-2-hydroxyethyl)benzofuran hydrochloride is obtained. M.p.=160-161° C.

Workup

  1. concentrationThe salt is concentrated under vacuum
  2. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-c1ce0b11e9274ec8b3c23b4b127a8f3a
Source dataset
uspto-grants-2000_05
Patent number
US06060508

Reaction notes

Loading…