Hydrochloric Acid → 2,3-Dimethyl-7-[1,2-di(diethylamino)ethyl]benzofuran hydrochloride

HRID 1107515Notes

Reaction equation

HRID 1107515 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7].[ClH:24]>C(O)(C)C>[ClH:24].[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 187875122,3-Dimethyl-7-[1,2-di(diethylamino)ethyl]benzofuran

Product 1

HCID 187875172,3-Dimethyl-7-[1,2-di(diethylamino)ethyl]benzofuran hydrochlorideYield 88%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

400 mg of 2,3-dimethyl-7-[1,2-di(diethylamino)ethyl]benzofuran and 10 ml of a solution of hydrochloric acid in isopropanol are placed in a 100 ml round-bottomed flask. The salt is concentrated under vacuum and recrystallized from ethyl acetate. 400 mg (Yield: 88%) of 2,3-dimethyl-7-[1,2-di(diethylamino)ethyl]benzofuran hydrochloride are obtained. M.p.=183° C.

Workup

  1. concentrationThe salt is concentrated under vacuum
  2. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-3f31e1e48eff4a38b4f31232b7f4100e
Source dataset
uspto-grants-2000_05
Patent number
US06060508

Reaction notes

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