Hydrochloric Acid → HCID 18787506, compound

HRID 1107521Notes

Reaction equation

HRID 1107521 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH3:13])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7].[ClH:19]>C(O)(C)C>[ClH:19].[CH3:1][C:2]1[O:3][C:4]2[C:11]([CH:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[CH3:13])=[CH:10][CH:9]=[CH:8][C:5]=2[C:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18787507HCID 18787507, compound

Product 1

HCID 18787506HCID 18787506, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.2 g (0.81 mmol) of 2,3-dimethyl-7-[l-(diethylamino)ethyl]benzofuran and 2 ml of a 6N solution of hydrochloric acid in isopropanol are placed in a 100 ml round-bottomed flask. The salt is concentrated under vacuum and recrystallized from ethyl acetate and diisopropyl ether. 0.142 g (Yield: 61%) of 2,3-dimethyl-7-[1-(diethylamino)ethyl]benzofuran hydrochloride is obtained in the form of a solid. M.p.=28-30° C.

Workup

  1. concentrationThe salt is concentrated under vacuum
  2. customrecrystallized from ethyl acetate and diisopropyl ether

Sources & evidence

ORD record
ord-368fda87255a4efeb6c9c5cf161f05b8
Source dataset
uspto-grants-2000_05
Patent number
US06060508

Reaction notes

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