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0 °C

A stirred mixture of ethyl 4-[5-fluoro-3-[4-(2-methylimidazol-1-yl)benzyloxy]phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate (Example 2) (1.10 g, 25 mmol), an aqueous solution of lithium hydroxide (0.13 g, 30 mmol, 5 ml), methanol (15 ml) and THF (15 ml) was refluxed for 24 hr. The reaction mixture was neutralized with 1N hydrogen chloride. Volatiles were removed by evaporation under reduced pressure. The residue was suspended into a mixture of water (20 ml) and phosphate buffer (pH=7, 5 ml) and heated to reflux for 30 min. After cooling to 0° C., solids were collected by filtration, washed with water and then with ether and dried to constant weight under vacuum at 80° C. for 14 hr to afford the titled compound as white solids (0.98 g, 96%).

1. customVolatiles were removed by evaporation under reduced pressure
2. additionThe residue was suspended into a mixture of water (20 ml) and phosphate buffer (pH=7, 5 ml)
3. temperatureheated
4. temperatureto reflux for 30 min
5. filtrationsolids were collected by filtration
6. washwashed with water
7. dry with materialwith ether and dried to constant weight under vacuum at 80° C. for 14 hr