反应详情

To a mixture of methyl 2-propylindole-6-carboxylate (10 g), methoxyacetic acid (4.6 ml) and carbontetrachloride (13.4 ml) in 1,2-dichloroethane (45 ml) was added slowly triphenylphosphine (16.7 g) in 1,2-dichloroethane (30 ml) over 1 hour under reflux, and the resulting mixture was heated under reflux for additional 8 hours. After evaporation of solvent, the residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate (1:1) and triturated with diethyl ether to give methyl 3-methoxyacetyl-2-propylindole-6-carboxylate (8.11 g).

1. temperatureunder reflux
2. temperaturethe resulting mixture was heated
3. temperatureunder reflux for additional 8 hours
4. customAfter evaporation of solvent
5. customthe residue was chromatographed on silica gel eluting with a mixture of hexane and ethyl acetate (1:1)
6. customtriturated with diethyl ether