Triethylamine → N-(2-(3,3-dimethylbut-1-ynyl)-3-fluorophenyl)butyramide

HRID 110947Notes

Reaction equation

HRID 110947 reaction equation
[Br:1][c:2]1[c:3]([NH:9][C:10]([CH2:11][CH2:12][CH3:13])=[O:14])[cH:4][cH:5][cH:6][c:7]1[F:8].[CH3:15][C:16]([C:17]#[C:18][CH3:19])([CH3:20])[CH3:21].[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[Cu:29][I:30].[Pd:31]([Cl:32])[Cl:33].[c:34]1([P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[cH:48][cH:49][cH:50][cH:51][cH:52]1.[c:53]1([P:54]([c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[cH:67][cH:68][cH:69][cH:70][cH:71]1>>[c:2]1([C:18]#[C:17][C:16]([CH3:15])([CH3:20])[CH3:21])[c:3]([NH:9][C:10]([CH2:11][CH2:12][CH3:13])=[O:14])[cH:4][cH:5][cH:6][c:7]1[F:8]

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 1367864,4-Dimethyl-2-pentyneHCID 59129259N-(2-bromo-3-fluorophenyl)butyramide

Product 1

HCID 59129310N-(2-(3,3-dimethylbut-1-ynyl)-3-fluorophenyl)butyramide

Sources & evidence

ORD record
ord-888f0c42427b4df9b866d1a7febdaee8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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