Potassium Carbonate → HCID 19020657, compound

HRID 1109495Notes

Reaction equation

HRID 1109495 reaction equation
[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[N:12]([CH2:16][CH2:17][C:18](=[O:20])[CH3:19])[CH:11]=[N:10][C:9]=3[NH:8][C:6]2=[O:7])[CH2:3][CH2:2]1.Br[CH2:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:1]1([CH2:4][N:5]2[C:14](=[O:15])[C:13]3[N:12]([CH2:16][CH2:17][C:18](=[O:20])[CH3:19])[CH:11]=[N:10][C:9]=3[N:8]([CH2:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)[C:6]2=[O:7])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 137636Cyclohexane, (bromomethyl)-HCID 19020648HCID 19020648, compound

Product 1

HCID 19020657HCID 19020657, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared by stirring 1-cyclopropylmethyl-7-(3-oxobutyl)xanthine, 5 g, with 4.6 mls of bromomethylcyclohexane and 5.2 g of potassium carbonate in 30 ml DMF over 5 hours. After evaporation of the solvent the title compound was purified by column chromatography (ether).

Workup

  1. customAfter evaporation of the solvent the title compound
  2. customwas purified by column chromatography (ether)

Sources & evidence

ORD record
ord-3c83bc80f7194cb2b8d3f6a2d497b244
Source dataset
uspto-grants-1994_06
Patent number
US05321029

Reaction notes

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