Potassium Carbonate → HCID 19020641, compound

HRID 1109497Notes

Reaction equation

HRID 1109497 reaction equation
[CH2:1]([N:8]1[C:16]2[N:15]=[CH:14][N:13]([CH2:17][C:18](=[O:20])[CH3:19])[C:12]=2[C:11](=[O:21])[NH:10][C:9]1=[O:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:24][CH:25]1[CH2:27][CH2:26]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH:25]1([CH2:24][N:10]2[C:11](=[O:21])[C:12]3[N:13]([CH2:17][C:18](=[O:20])[CH3:19])[CH:14]=[N:15][C:16]=3[N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]2=[O:22])[CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 19020655HCID 19020655, compound

Product 1

HCID 19020641HCID 19020641, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

18.1 g of 3-benzyl-7-(2-oxopropyl)xanthine were treated with 11.4 ml of bromomethylcyclopropane and 9.2 g of potassium carbonate in 150 ml of DMF for 3 hours at 70° C. The mixture was concentrated, water was added and the product was extracted with ethyl acetate. After concentration of the solution the product crystallised, m.p. 138° C.

Workup

  1. concentrationThe mixture was concentrated
  2. additionwater was added
  3. extractionthe product was extracted with ethyl acetate
  4. customAfter concentration of the solution the product crystallised

Sources & evidence

ORD record
ord-0cad65cbcb164249a820c6bf3b169ab5
Source dataset
uspto-grants-1994_06
Patent number
US05321029

Reaction notes

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