反应详情

温度

5 °C

A 3.3N solution (6.2 cc) of hydrochloric acid in isopropyl ether is added dropwise in the course of 5 minutes to a solution of N-propyl-10-[1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide, L series (7.2 g), in anhydrous ethyl acetate (80 cc). The product deposits on the walls and crystallizes on scratching. The suspension obtained is maintained for one hour at a temperature in the region of 5° C. The solid is drained, washed with anhydrous ethyl acetate (3×5 cc) and dried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C. to give N-propyl-10-[1-(1-pyrroli-dinyl)-2-propyl]-2-phenothiazinecarboxamide hydrochloride, L series (7.1 g), in the form of a white solid, m.p. 190° C.

1. customThe product deposits on the walls and crystallizes
2. customThe suspension obtained
3. washwashed with anhydrous ethyl acetate (3×5 cc)
4. customdried under reduced pressure (5 mm Hg; 0.7 kPa) at 40° C.