4-Aminophenol → HCID 19019453, compound

HRID 1109763Notes

Reaction equation

HRID 1109763 reaction equation
[OH:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[N+:14]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:22]=1Cl)([O-:16])=[O:15]>C(O)C>[N+:14]([C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:22]=1[NH:6][C:5]1[CH:7]=[CH:8][C:2]([OH:1])=[CH:3][CH:4]=1)([O-:16])=[O:15]

Participants

5

Reactant 3

HCID 4034-AminophenolHCID 516892Sodium BicarbonateHCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 19019453HCID 19019453, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a stirred mixture of 50.2 g of p-hydroxyaniline and 38.7 g of sodium bicarbonate in 1.5 1 of ethanol was added dropwise 73 g of 3-nitro-4-chloropyridine in 2.0 l of ethanol. After stirring overnight at room temperature, the resulting solids were filtered, washed with water (2 l) and dried, 85.4 g.

Workup

  1. filtrationthe resulting solids were filtered
  2. washwashed with water (2 l)
  3. customdried

Sources & evidence

ORD record
ord-41b80e5f9d904910a10ef2bd29c76d67
Source dataset
uspto-grants-1994_06
Patent number
US05322847

Reaction notes

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