Triethylamine → HCID 9904687, compound

HRID 1109807Notes

Reaction equation

HRID 1109807 reaction equation
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][O:9][C:10]([N:12]2[CH2:16][C@H:15]([S:17](C)(=O)=O)[CH2:14][C@H:13]2[C:21](=S)[OH:22])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].P([O-])([O-])(O)=O.[Na+].[Na+].C(N(CC)CC)C>C(Cl)Cl.O1CCCC1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10]([N:12]2[CH2:16][C@@H:15]3[CH2:14][C@H:13]2[C:21](=[O:22])[S:17]3)=[O:11])=[CH:24][CH:25]=1)([O-:3])=[O:2]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 24203Sodium Phosphate, DibasicHCID 178504907HCID 178504907, compound

Product 1

HCID 9904687HCID 9904687, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

For example, (2S,4R)-1-p-nitrobenzyloxycarbonyl -4-methanesulfonyl-2-pyrrolidinethiocarboxylic acid is allowed to react with disodium hydrogenphosphate or triethylamine in methylene chloride or tetrahydrofuran, thereby to give (1S,4S)-5-p-nitrobenzyloxycarbonyl-2-thia-5-azabicyclo[2.2.1]heptan-3-one.

Sources & evidence

ORD record
ord-2665c7cbce56476595827e08561e3fcd
Source dataset
uspto-grants-1994_06
Patent number
US05322952

Reaction notes

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