Chlorosuccinimide → HCID 19019911, compound

HRID 1109828Notes

Reaction equation

HRID 1109828 reaction equation
[Cl:1][C:2]1[CH2:3][C:4]([C:12]([O:14][CH3:15])=[O:13])=[C:5]([CH2:10][CH:11]=1)[C:6]([O:8][CH3:9])=[O:7].[Cl:16]N1C(=O)CCC1=O.C1C=CN=CC=1.[FH:30]>C(Cl)Cl>[CH3:15][O:14][C:12](=[O:13])[C:4]1[CH2:3][CH:2]([Cl:1])[C:11]([Cl:16])([F:30])[CH2:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

Participants

5

Reactant 3

HCID 31398ChlorosuccinimideHCID 64774Pyridine, hydrofluoride (1:1)HCID 19019908HCID 19019908, compound

Product 1

HCID 19019911HCID 19019911, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Dimethyl 4-chloro-3,6-dihydrophthalate (1.1 g) and N-chlorosuccinimide (0.6 g) in methylene chloride (4.1 g) was added to pyridinium poly(hydrogen fluoride) (3.1 g) at room temperature. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was carefully poured into methylene chloride containing solid sodium carbonate. The methylene chloride layer was filtered and dried with magnesium sulfate and the solvent removed under reduced pressure.

Workup

  1. filtrationThe methylene chloride layer was filtered
  2. dry with materialdried with magnesium sulfate
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-ceb626f7d4d349e8a9cc760b29d95cf7
Source dataset
uspto-grants-1994_06
Patent number
US05322954

Reaction notes

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