Potassium Carbonate → HCID 15163161, compound

HRID 1110043Notes

Reaction equation

HRID 1110043 reaction equation
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][CH2:7]2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>CN(C=O)C>[CH2:22]([N:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8][CH2:7]2)[CH2:3][CH2:2]1)[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 125271-IodohexaneHCID 156376162,3-Dihydrospiro(indene-1,4'-piperidine)

Product 1

HCID 15163161HCID 15163161, compoundYield 52.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same way as that described in Example 1, step 5, the title compound was synthesised using spiro[indane-1,4'-piperidine] (0.4 g, 2.2 mmol), DMF (15 ml), potassium carbonate (0.33 g, 2.4 mmol) and iodohexane (0.62 g, 2.9 mmol). The crude residue was chromatographed in 1:1 petrol:ether to give 1'-hexylspiro[indane-1,4'-piperidine] (314 mg, 52%) as a pale yellow oil.

Workup

  1. customthe title compound was synthesised
  2. customThe crude residue was chromatographed in 1:1 petrol

Sources & evidence

ORD record
ord-b711090b63ee4a9ab4dd6471ffd324fd
Source dataset
uspto-grants-1994_06
Patent number
US05324733

Reaction notes

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