反应详情

A mixture of 5-chloro-2-nitrobenzaldehyde (47.0 g., 0.25 mole), 2-cyanoacetamide (21.0 g., 0.25 mole), diethylamine (0.5 ml.) and ethanol (500 ml is heated at reflux for 1 hour. Sodium ethoxide (10 mg.) is added to the clear mixture and refluxing continued for an additional 2.5 hours. It is then cooled and the crystalline product which precipitates recovered by filtration. Yield = 52.3 g. (88%); m.p. of crude = 183°-185° C. It is used without purification in step B.

1. temperatureis heated
2. temperatureat reflux for 1 hour
3. temperaturerefluxing
4. temperatureIt is then cooled
5. customthe crystalline product which precipitates
6. filtrationrecovered by filtration
7. customm.p. of crude = 183°-185° C
8. customIt is used without purification in step B