Triethylamine → HCID 131711306, compound

HRID 1112337Notes

Reaction equation

HRID 1112337 reaction equation
C(N(CC)CC)C.[NH2:8][C@H:9]([C:17]([O:19][CH3:20])=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.Cl.[NH:22]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[C@H:23]([C:31]([OH:33])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>O1CCCC1>[C:37]([O:36][C:34]([NH:22][C@H:23]([C:31]([OH:33])=[O:32])[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:35])([CH3:40])([CH3:38])[CH3:39].[CH3:20][O:19][C:17](=[O:18])[C@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[NH2:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 75736Methyl L-phenylalaninate hydrochlorideHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

Product 1

HCID 131711306HCID 131711306, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

788 mg of triethylamine are added to a mixture of 648 mg of Phe-OMe.HCl and 1.641 g of Boc-Phe≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the mixture becomes deep red. It is stirred for 1 hour at 20° C. The pale yellow mixture is then worked up as described in Example D 1.

Sources & evidence

ORD record
ord-00690b1ecae944af8ebeb023e864d2b5
Source dataset
uspto-grants-1978_10
Patent number
US04122090

Reaction notes

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