Triethylamine → HCID 131711310, compound

HRID 1112340Notes

Reaction equation

HRID 1112340 reaction equation
C(N(CC)CC)C.N1CCC[C@H]1C(N1CCC[C@H]1C(N[C@H](C([NH:27][C@H:28]([C:36]([O:38][CH3:39])=[O:37])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=O)CC1C=CC=CC=1)=O)=O.Cl.[NH:47]([C:59]([O:61][C:62]([CH3:65])([CH3:64])[CH3:63])=[O:60])[C@H:48]([C:56]([OH:58])=[O:57])[CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1>O1CCCC1>[C:62]([O:61][C:59]([NH:47][C@H:48]([C:56]([OH:58])=[O:57])[CH2:49][C:50]1[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=1)=[O:60])([CH3:65])([CH3:63])[CH3:64].[NH:47]1[CH2:59][CH2:50][CH2:49][C@H:48]1[C:56]([OH:58])=[O:57].[NH:47]1[CH2:59][CH2:50][CH2:49][C@H:48]1[C:56]([OH:58])=[O:57].[NH2:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[CH3:39][O:38][C:36](=[O:37])[C@H:28]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[NH2:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-HCID 131711311HCID 131711311, compound

Product 1

HCID 131711310HCID 131711310, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

420 mg of triethylamine are added to a mixture of 891 mg of Pro-Pro-Phe-Phe-OMe.HCl D 14 and 875 mg of Boc-Phe≈SO2 in 20 ml of absolute tetrahydrofuran, whereupon the mixture develops a deep red coloration. It is stirred for 2 hours at 20° C. The pale yellow mixture is then worked up as described in Example D 1.

Sources & evidence

ORD record
ord-26313fc4190c436bb110c7f87ac1beeb
Source dataset
uspto-grants-1978_10
Patent number
US04122090

Reaction notes

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