Dimethylformamide → N-(1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-yl)-2-cyanoacetamide
Reaction equation
[C:1](#[N:2])[CH2:3][C:4](=[O:5])[OH:6].[Cl:43][CH2:44][Cl:45].[Cl:7][C:8]([C:9]([Cl:10])=[O:11])=[O:12].[NH2:13][CH:14]1[CH2:15][CH2:16][N:17]([c:20]2[n:21][c:22]([NH:27][c:28]3[cH:29][cH:30][c:31]([N:34]4[CH2:35][CH2:36][N:37]([C:40]([CH3:41])=[O:42])[CH2:38][CH2:39]4)[cH:32][cH:33]3)[n:23][cH:24][c:25]2[F:26])[CH2:18][CH2:19]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50]>>[C:1](#[N:2])[CH2:3][C:4](=[O:6])[NH:13][CH:14]1[CH2:15][CH2:16][N:17]([c:20]2[n:21][c:22]([NH:27][c:28]3[cH:29][cH:30][c:31]([N:34]4[CH2:35][CH2:36][N:37]([C:40]([CH3:41])=[O:42])[CH2:38][CH2:39]4)[cH:32][cH:33]3)[n:23][cH:24][c:25]2[F:26])[CH2:18][CH2:19]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-f3aa1f7f90a64cec85e940ca13ba1f00
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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