Tetrahydrofuran → (RS)-N-(4-cyano-benzyl)-2-methoxy-2-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-acetamide

HRID 1115628Notes

Reaction equation

HRID 1115628 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][C:9]([CH:10]([O:11][CH3:12])[c:13]2[cH:14][cH:15][c:16]([OH:19])[cH:17][cH:18]2)=[O:20])[cH:21][cH:22]1.[CH2:62]1[O:63][CH2:64][CH2:65][CH2:66]1.[O:50]=[C:51]([O:52][CH2:53][CH3:54])[N:55]=[N:56][C:57]([O:58][CH2:59][CH3:60])=[O:61].[OH:42][CH:43]1[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]1.[c:23]1([P:24]([c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][C:9]([CH:10]([O:11][CH3:12])[c:13]2[cH:14][cH:15][c:16]([O:19][CH:43]3[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]3)[cH:17][cH:18]2)=[O:20])[cH:21][cH:22]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 660484-Piperidinol, 1-methyl-HCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 21905457(RS)-N-(4-cyano-benzyl)-2-(4-hydroxy-phenyl)-2-methoxy-acetamide

Product 1

HCID 21905410(RS)-N-(4-cyano-benzyl)-2-methoxy-2-[4-(1-methyl-piperidin-4-yloxy)-phenyl]-acetamide

Sources & evidence

ORD record
ord-05a9a1658d0d4c37a096c5e238cb4474
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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