Dimethylformamide → [5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

HRID 1117125Notes

Reaction equation

HRID 1117125 reaction equation
[B-:21]([F:22])([F:23])([F:24])[F:25].[CH2:1]([O:2][C:4](=[O:5])[c:6]1[n:7]([CH2:16][C:17]([F:18])([F:19])[F:20])[c:8]2[cH:9][cH:10][c:11]([OH:15])[cH:12][c:13]2[cH:14]1)[CH3:3].[CH2:43]1[CH2:44][O:45][CH2:46][CH2:47][NH:48]1.[CH2:49]([N:50]([CH:51]([CH3:52])[CH3:53])[CH:54]([CH3:55])[CH3:56])[CH3:57].[CH3:58][N:59]([CH3:60])[CH:61]=[O:62].[CH3:63][CH2:64][O:65][C:66](=[O:67])[CH3:68].[n:26]1([O:27][C:28]([N:29]([CH3:30])[CH3:31])=[N+:32]([CH3:33])[CH3:34])[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]2[n:41][n:42]1>>[C:4](=[O:5])([c:6]1[n:7]([CH2:16][C:17]([F:18])([F:19])[F:20])[c:8]2[cH:9][cH:10][c:11]([OH:15])[cH:12][c:13]2[cH:14]1)[N:48]1[CH2:43][CH2:44][O:45][CH2:46][CH2:47]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 8083MorpholineHCID 8857Ethyl AcetateHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 24985291Ethyl 5-hydroxy-1-(2,2,2-trifluoroethyl)-1H-indole-2-carboxylate

Product 1

HCID 67527268[5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

Sources & evidence

ORD record
ord-b28cbe2528cf411eaa39a7e22f78277f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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