4-Methylmorpholine → 8-(1-((3,5-difluorophenyl)(methyl)amino)ethyl)-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholino-4H-chromen-4-one

HRID 1117856Notes

Reaction equation

HRID 1117856 reaction equation
[CH3:33][N:34]1[CH2:35][CH2:36][O:37][CH2:38][CH2:39]1.[CH3:47][N:48]1[CH2:49][CH2:50][CH2:51][C:52]1=[O:53].[F:1][c:2]1[cH:3][c:4]([N:9]([CH:10]([CH3:11])[c:12]2[cH:13][c:14]([C:29](=[O:30])[OH:31])[cH:15][c:16]3[c:17](=[O:28])[cH:18][c:19]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[o:20][c:21]23)[CH3:32])[cH:5][c:6]([F:8])[cH:7]1.[NH:40]1[CH2:41][CH2:42][CH:43]([OH:46])[CH2:44][CH2:45]1>>[F:1][c:2]1[cH:3][c:4]([N:9]([CH:10]([CH3:11])[c:12]2[cH:13][c:14]([C:29](=[O:30])[N:40]3[CH2:41][CH2:42][CH:43]([OH:46])[CH2:44][CH2:45]3)[cH:15][c:16]3[c:17](=[O:28])[cH:18][c:19]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)[o:20][c:21]23)[CH3:32])[cH:5][c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 79724-MethylmorpholineHCID 13387N-methyl-2-pyrrolidoneHCID 79341Piperidin-4-olHCID 582349758-(1-((3,5-difluorophenyl)(methyl)amino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid

Product 1

HCID 582349708-(1-((3,5-difluorophenyl)(methyl)amino)ethyl)-6-(4-hydroxypiperidine-1-carbonyl)-2-morpholino-4H-chromen-4-one

Sources & evidence

ORD record
ord-6a0acd2da616407f9d8c788f07a268e8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…