Tetrahydrofuran → 7-{2-[3-(2-Ethoxycarbonyl-ethyl)-benzo[b]thiophen-6-yloxy]-ethyl}-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester

HRID 1118332Notes

Reaction equation

HRID 1118332 reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH2:28][c:29]2[cH:30][cH:31][c:32]([CH2:35][CH2:36][OH:37])[n:33][c:34]21.[CH2:71]1[O:72][CH2:73][CH2:74][CH2:75]1.[O:57]=[C:58]([O:59][CH:60]([CH3:61])[CH3:62])[N:63]=[N:64][C:65]([O:66][CH:67]([CH3:68])[CH3:69])=[O:70].[OH:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([s:7][cH:8][c:9]2[CH2:10][CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[cH:17]1.[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1>>[O:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([s:7][cH:8][c:9]2[CH2:10][CH2:11][C:12](=[O:13])[O:14][CH2:15][CH3:16])[cH:17]1)[CH2:36][CH2:35][c:32]1[cH:31][cH:30][c:29]2[c:34]([n:33]1)[N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:26][CH2:27][CH2:28]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 11288155Ethyl 3-(6-hydroxybenzo[B]thiophen-3-YL)propanoateHCID 58230650tert-Butyl 7-(2-hydroxyethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate

Product 1

HCID 695481007-{2-[3-(2-Ethoxycarbonyl-ethyl)-benzo[b]thiophen-6-yloxy]-ethyl}-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-2236ee1356fc4efa9ffa9f94cc3d9762
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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