Ammonium → tert-Butyl 4-hydroxy-4-(4-(trifluoromethoxy)phenyl)piperidine-1-carboxylate
Reaction equation
[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH2:27][C:28](=[C:31]=[O:32])[CH2:29][CH2:30]1.[CH2:13]([Li:14])[CH2:15][CH2:16][CH3:17].[Cl-:33].[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([Br:10])[cH:8][cH:9]1)([F:11])[F:12].[NH4+:34].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([C:28]2([OH:35])[CH2:27][CH2:26][N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:30][CH2:29]2)[cH:8][cH:9]1)([F:11])[F:12]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-396b577e815e48e0be77584c510e66c3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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