Triethylamine → N-cyclopropyl-4-methyl-3-(2-(6-(2-morpholinoethylamino)pyridin-3-yl)ethynyl)benzamide

HRID 1121045Notes

Reaction equation

HRID 1121045 reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][cH:5][c:6]([NH:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[n:7][cH:8]1.[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50].[CH:18]1([NH:21][C:22]([c:23]2[cH:24][c:25]([I:30])[c:26]([CH3:29])[cH:27][cH:28]2)=[O:31])[CH2:19][CH2:20]1.[Cu:51][I:52].[O:39]1[CH2:40][CH2:41][O:42][CH2:43][CH2:44]1>>[C:1](#[C:2][c:25]1[cH:24][c:23]([C:22]([NH:21][CH:18]2[CH2:19][CH2:20]2)=[O:31])[cH:28][cH:27][c:26]1[CH3:29])[c:3]1[cH:4][cH:5][c:6]([NH:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[n:7][cH:8]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 21914546N-Cyclopropyl-3-iodo-4-methylbenzamideHCID 594279395-ethynyl-N-(2-morpholinoethyl)pyridin-2-amine

Product 1

HCID 59427921N-cyclopropyl-4-methyl-3-(2-(6-(2-morpholinoethylamino)pyridin-3-yl)ethynyl)benzamide

Sources & evidence

ORD record
ord-2d8c1c1162364ea8a2e4d7378b46cc40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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