Bromide ion → 7-chloro-4-(2,5-dimethyl-1H-indol-3-yl)quinoline

HRID 1121067Notes

Reaction equation

HRID 1121067 reaction equation
[Br-:12].[CH2:13]([Mg+:14])[CH3:15].[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:1][c:2]1[nH:3][c:4]2[cH:5][cH:6][c:7]([CH3:11])[cH:8][c:9]2[cH:10]1.[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33].[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[Cl:16][c:17]1[cH:18][cH:19][n:20][c:21]2[cH:22][c:23]([Cl:27])[cH:24][cH:25][c:26]12.[OH2:46]>>[CH3:1][c:2]1[nH:3][c:4]2[cH:5][cH:6][c:7]([CH3:11])[cH:8][c:9]2[c:10]1-[c:17]1[cH:18][cH:19][n:20][c:21]2[cH:22][c:23]([Cl:27])[cH:24][cH:25][c:26]12

Participants

9

Reactant 8

HCID 259Bromide ionHCID 962WaterHCID 1140TolueneHCID 68664,7-DichloroquinolineHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 709652,5-Dimethyl-1H-indoleHCID 178461628HCID 178461628, compound

Product 1

HCID 111625767-chloro-4-(2,5-dimethyl-1H-indol-3-yl)quinoline

Sources & evidence

ORD record
ord-898762f41a854affa4a153166bb864e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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