Dimethylformamide → {2-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilany-ethoxy)-1,3-dihydro-isobenzofuran-5-yl]-ethoxymethyl}-phosphonic Acid Diisopropyl Ester

HRID 1121918Notes

Reaction equation

HRID 1121918 reaction equation
[CH3:36][C:37]([CH3:38])([O-:39])[CH3:40].[CH:24]([CH3:25])([CH3:26])[O:27][P:28]([O:29][CH:30]([CH3:31])[CH3:32])(=[O:33])[CH2:34][Br:35].[Li+:41].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[OH:1][CH2:2][CH2:3][c:4]1[c:5]([O:22][CH3:23])[c:6]([CH3:21])[c:7]2[c:11]([c:12]1[O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[C:10](=[O:20])[O:9][CH2:8]2>>[O:1]([CH2:2][CH2:3][c:4]1[c:5]([O:22][CH3:23])[c:6]([CH3:21])[c:7]2[c:11]([c:12]1[O:13][CH2:14][CH2:15][Si:16]([CH3:17])([CH3:18])[CH3:19])[C:10](=[O:20])[O:9][CH2:8]2)[CH2:34][P:28]([O:27][CH:24]([CH3:25])[CH3:26])([O:29][CH:30]([CH3:31])[CH3:32])=[O:33]

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 28486Lithium ionHCID 4366885Diisopropyl bromomethylphosphonateHCID 45749132-Methylpropan-2-olateHCID 574598516-(2-Hydroxy-ethyl)-5-methoxy-4-methyl-7-(2-trimethylsilanyl-ethoxy)-3H-isobenzofuran-1-one

Product 1

HCID 57478687{2-[6-Methoxy-7-methyl-3-oxo-4-(2-trimethylsilany-ethoxy)-1,3-dihydro-isobenzofuran-5-yl]-ethoxymethyl}-phosphonic Acid Diisopropyl Ester

Sources & evidence

ORD record
ord-d010f779adf24a4194bc8584ef8340dc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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